Bayesian model comparison in genetic association analysis: linear mixed modeling and SNP set testing.

Supplementary Material for “Bayesian Model Comparison in Genetic Association Analysis: Linear Mixed Modeling and SNP Set Testing”

Quantitative Modeling for Prediction of Critical Temperature of Refrigerant Compounds

The quantitative structure-property relationship (QSPR) method is used to develop the correlation between structures of refrigerants (198 compounds) and their critical temperature. Molecular descriptors calculated from structure alone were used to represent molecular structures. A subset of the calculated descriptors selected using a genetic algorithm (GA) was used in the QSPR model development...

Comparison of Linear and Threshold Models for Estimation Genetic and Phenotypic Parameters of Success of Conception at First Service and Inseminations to Conception in Holstein Cattles in East Azarbayjan Province

In this research genetic and phenotypic parameters were estimated using linear and threshold models, for reproductive traits, data from 6 large industrial dairy herd of East Azerbaijan province collected by Agriculture Jihad Organization during 10 years (2001-2010). Best linear unbiased predictions of traits breeding values were estimated using Restricted Maximum Likelihood method by WOMBAT sof...

Comparison of Linear and Threshold Models for Estimation Genetic and Phenotypic Parameters of Success of Conception at First Service and Inseminations to Conception in Holstein Cattles in East Azarbayjan Province

In this research genetic and phenotypic parameters were estimated using linear and threshold models, for reproductive traits, data from 6 large industrial dairy herd of East Azerbaijan province collected by Agriculture Jihad Organization during 10 years (2001-2010). Best linear unbiased predictions of traits breeding values were estimated using Restricted Maximum Likelihood method by WOMBAT sof...

Powerful SNP-set analysis for case-control genome-wide association studies.

GWAS have emerged as popular tools for identifying genetic variants that are associated with disease risk. Standard analysis of a case-control GWAS involves assessing the association between each individual genotyped SNP and disease risk. However, this approach suffers from limited reproducibility and difficulties in detecting multi-SNP and epistatic effects. As an alternative analytical strate...